{ "acceptance_criteria": [ "Every r in R_cal finishes or is explicit HOLD", "Diagnosis remains sealed", "PTSD nuclei remain excluded", "Original ENSG row order unchanged", "No AST_MEMBERSHIP_FREEZE", "No single privileged resolution declared as biological truth", "Admissible set size is not 0 or 1, or the report is HOLD", "IMPLEMENTATION_CHECK records Pegasus with registered kwargs (no Scanpy substitute, no live library defaults)", "If r=0.4 or r=2.4 is admissible, report RANGE_BOUNDARY_NOT_BRACKETED and do not claim a complete range", "If any required grid point is unfinished, calibration is HOLD/INCOMPLETE and does not claim a complete range", "marker_separability is HOLD_NOT_RUN unless a frozen public panel identity/hash was resolved before freeze" ], "canonical_stop": "WAITING_FOR_INVESTIGATOR_REVIEW", "cloud_environment_manifest_sha256": "0fe8e83f3513bd9766faae0b7175fb393bfbe160272798b7089fbf4890c2de7c", "contract_body_sha256": "05b746e5aafcbe67e352273f63fdf44ec7c2ccc4b88757355acacd386205a27c", "excluded_scope": "Do not run clustering GO, annotation, unblind, DE, pathway, PTSD inclusion, P1 C2 copy, OPEN_01 auto-approval, production ENSG remapping, or scientific GO change. Do not use diagnosis, AST count-max, Channel balance, P1 concordance, 241/DEG, or Hwang ST2 AST fraction as selection targets. Do not use P1 8-gene panel. Do not open the restricted diagnosis asset. UMAP is sanity only and does not define identity. 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grid/seeds/guardrails unchanged", "forbidden_selection_targets": [ "diagnosis", "AST_count_max", "channel_balance_optimization", "P1_C2_concordance", "DEG_241", "Hwang_ST2_AST_fraction", "UMAP_aesthetics" ], "g3b_operational_subset": [ 0.6, 1.2, 1.8 ], "grid": [ 0.4, 0.6, 1.0, 1.2, 1.6, 1.8, 2.4 ], "guardrails": { "GAP_WEAK": "DELETED", "admissible_set_size_0_or_1": "HOLD", "collapse_if_n_clusters_lt": 7, "incomplete_grid": { "claim_complete_admissible_range": false, "if_any_required_grid_point_unfinished": "HOLD/INCOMPLETE", "may_report_completed_diagnostics": true }, "marker_separability": "diagnostic distribution only; no pass/fail cutoff; requires frozen public panel identity/hash", "overfragment_if_frac_clusters_size_lt_50_gt": 0.25, "overfragment_if_n_clusters_gt": 80, "overfragment_if_seed_ari_median_lt": 0.7, "range_boundary": { "claim_complete_admissible_range": false, "follow_up": "later grid-extension contract", "highest_r": 2.4, "if_lowest_or_highest_still_admissible": "RANGE_BOUNDARY_NOT_BRACKETED", "lowest_r": 0.4 } }, "harmony_covariate": "Channel", "hvg_batch": "Channel", "hvg_n_top": 2000, "implementation": { "family": "Pegasus", "harmony": { "batch": "Channel" }, "hvg": { "batch": "Channel", "fn": "highly_variable_features", "n_top": 2000 }, "log_norm": "pg.log_norm; 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Do not assign class labels. Marker-panel gaps are diagnostic distributions only (no GAP_WEAK cutoff) and run only if a frozen public panel identity/hash is resolved; otherwise HOLD_NOT_RUN.", "task_id": "b0780b59-f106-4e0a-8795-12790307aab0", "test_only": false, "title": "P2 resolution calibration (phenotype-blind, MDD+CON 625220)", "webpage_is_not_scientific_authorization": true }