{
  "acceptance_criteria": [
    "Every r in R_cal finishes or is explicit HOLD",
    "Diagnosis remains sealed",
    "PTSD nuclei remain excluded",
    "Original ENSG row order unchanged",
    "No AST_MEMBERSHIP_FREEZE",
    "No single privileged resolution declared as biological truth",
    "Report states recommended range and selection basis, or HOLD with reason"
  ],
  "canonical_stop": "WAITING_FOR_INVESTIGATOR_REVIEW",
  "cloud_environment_manifest_sha256": "0fe8e83f3513bd9766faae0b7175fb393bfbe160272798b7089fbf4890c2de7c",
  "contract_body_sha256": "a5aebb334a39fd5ba8a9e0e7a6c6b8f41419bb3b6e895518b459ada637a48330",
  "excluded_scope": "Do not run clustering GO, annotation, unblind, DE, pathway, PTSD inclusion, P1 C2 copy, OPEN_01 auto-approval, production ENSG remapping, or scientific GO change. Do not use diagnosis, AST count-max, Channel balance, P1 concordance, 241/DEG, or Hwang ST2 AST fraction as selection targets. Do not use P1 8-gene panel. Do not open the restricted diagnosis asset. UMAP is sanity only and does not define identity.",
  "execution_runtime_release_id": "0.3.2-rc4-reviewpub-v2",
  "holds": [
    "OPEN_01 UNION_REMOVE remains unapproved; this task does not decide Round-1 merge",
    "Marker Hodge/Lake/Ma JSON not frozen; this task does not score class markers",
    "G2 specimen HOLD remains; this task is nucleus-level geometry only",
    "RNA gene identity ledger is audit-only; no remap",
    "CALIBRATION/CLUSTERING/ANNOTATION Record Core flags remain NOT_AUTHORIZED until a later approved execution actually records them",
    "CSR matrix is CLOUD_AUTHORITATIVE; execution must be on the registered cloud host after approval"
  ],
  "method_identity": "p2-task-contract/0.3.2-rc4",
  "objective": "Determine a phenotype-blind Leiden resolution range and selection basis for later P2 clustering. This freeze is not execution approval.",
  "output_assets": [],
  "project_id": "P2_HWANG",
  "record_checkpoint_id": "ckpt-1d9b0900-de09-4037-aaad-36d77ce380b9",
  "resolved_inputs": [
    {
      "access_mode": "local_read",
      "alias_zh": "P2 MDD+CON 聚类队列（625,220 / 70 Channels）",
      "asset_id": "P2_MDD_CON_CLUSTERING_COHORT_625220",
      "bytes": 21882716,
      "execution_location": "local",
      "execution_site": "LOCAL",
      "object_identity": null,
      "object_identity_status": "not_applicable",
      "path_withheld": true,
      "restricted": false,
      "restricted_class": "none",
      "role": "analysis_cohort",
      "selected_replica": "LOCAL",
      "sha256": "ffc9dcc707452e5b49ebd12132d3b2bff2143b1871bb59bbb1f45536bcd1e3f4",
      "status": "MATCH"
    },
    {
      "access_mode": "metadata_only",
      "alias_zh": "P2 计数矩阵（只公布逻辑名与哈希）",
      "asset_id": "P2_CSR_COUNT_MATRIX",
      "bytes": 5948837770,
      "execution_location": "cloud",
      "execution_site": "SSH_CLOUD",
      "object_identity": null,
      "object_identity_status": "not_applicable",
      "path_withheld": true,
      "restricted": false,
      "restricted_class": "none",
      "role": "count_matrix_csr",
      "selected_replica": "SSH_CLOUD",
      "sha256": "79876eda346f3a6c325a2cb33de9f35cfc2d276018b79462bd749a957b279922",
      "status": "MATCH"
    }
  ],
  "review_schema": "p2.contract_review_projection.v1",
  "runtime_manifest_sha256": "48aa6c4565667576180365be5b6addcea0ac9b3f176f10ee689f383b0254f92c",
  "schema": "p2.review_public_contract.v1",
  "schema_version": "p2-task-contract/0.3.2-rc4",
  "scientific_go": false,
  "scientific_parameters": {
    "calibration_spec": {
      "author_leiden_resolution": "NOT_FOUND",
      "forbidden_selection_targets": [
        "diagnosis",
        "AST_count_max",
        "channel_balance_optimization",
        "P1_C2_concordance",
        "DEG_241",
        "Hwang_ST2_AST_fraction",
        "UMAP_aesthetics"
      ],
      "g3b_operational_subset": [
        0.6,
        1.2,
        1.8
      ],
      "grid": [
        0.4,
        0.6,
        1.0,
        1.2,
        1.6,
        1.8,
        2.4
      ],
      "harmony_covariate": "Channel",
      "hvg_batch": "Channel",
      "hvg_n_top": 2000,
      "k_neighbors": 100,
      "n_pcs": 50,
      "ptsd_included": false,
      "seeds": [
        0,
        1,
        2
      ],
      "universe_asset_id": "P2_MDD_CON_CLUSTERING_COHORT_625220",
      "universe_n_channels": 70,
      "universe_n_nuclei": 625220
    },
    "csr_axis_semantics": null
  },
  "scientific_scope": "Accepted clustering universe = 625220 MDD+CON nuclei / 70 Channels. Embedding matches Hwang-public / G3b v0.2 geometry: robust genes, log-norm (counts retained), HVG 2000 by Channel, PCA 50, Harmony on Channel, neighbors k=100. Calibration grid R_cal = [0.4, 0.6, 1.0, 1.2, 1.6, 1.8, 2.4] with seeds [0, 1, 2]. G3b operational set {0.6, 1.2, 1.8} is included; author Leiden resolution remains NOT FOUND and is not invented. Metrics: n_clusters, size distribution, seed ARI, adjacent-r ARI, modularity if available. Selection basis: recommend a range (or HOLD) where clusters are neither collapsed below 7 nor exploded into many tiny clusters, and seed/adjacent stability is acceptable. Do not declare one biological true resolution. Do not assign class labels.",
  "task_id": "b90b5917-d077-4bff-8b6e-8307124e67a1",
  "test_only": false,
  "title": "P2 resolution calibration (phenotype-blind, MDD+CON 625220)",
  "webpage_is_not_scientific_authorization": true
}